Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

Background Inter-individual variability during sepsis limits appropriate triage of patients.
Identifying, at first clinical presentation, gene expression signatures that predict subsequent …

Over the last years, there have been advances in the use of data-driven techniques to
improve the definition, early recognition, subtypes characterisation, prognostication and …

Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate
and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare …

BACKGROUND Sepsis remains a major clinical challenge for which successful treatment
requires greater precision in identifying patients at increased risk of adverse outcomes …

Immune therapy to ease the burden of sepsis has thus far failed to consistently improve
patient outcomes. Advances in cancer immune therapy and awareness that prolonged …

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Sepsis represents a life-threatening organ dysfunction due to an aberrant host response. Of
note is that majority of patients have experienced a severe immune depression during and …

Decades of sepsis research into a specific immune system-targeting adjunctive therapy
have not resulted in the discovery of an effective compound. Apart from antibiotics, source …