Je mehr über die molekularen Eigenschaften, die zu Entstehung, Wachstum und
Metastasierung des kolorektalen Karzinoms führen, bekannt wird, desto größer wird der …

Bei 3-6% der Patienten liegt das KRK im Rahmen definierter genetischer Syndrome vor,
wohingegen 95% aller KRK sporadisch mit multifaktorieller Genese auftreten (Kanth et al …

Simple Summary The impact of aspirin use after the diagnosis of colorectal cancer is
unknown. Among others, PIK3CA mutational status was proposed as a molecular biomarker …

Background. Recent data have suggested that regular aspirin use improves overall and
cancer-specific survival in the subset of colorectal cancer (CRC) patients harboring PIK3CA …

e12594 Background: Regular aspirin (ASA) use has been associated with inhibition of the
whole spectrum of colorectal carcinogenesis, including prevention of metastases and …

386 Background: Recent data has demonstrated that regular ASA use improves overall and
cancer-specific survival in the subset of CRC patients harboring PIK3CA mutations …

Aims Regular aspirin use has been associated with inhibition of the whole spectrum of
colorectal carcinogenesis, including prevention of metastases and reduced total mortality in …

Purpose To evaluate clinicopathologic and molecular features of patients with metastatic
colorectal cancer (mCRC) and their outcomes in early-phase trials using pathway-targeting …

Study rationale The coexistence of KRAS and PIK3CA mutations in cells implies potential
synergistic hyperactivation of the Ras/MAPK and PI3K/Akt oncogenic pathways. Therefore, it …

Oxaliplatin-based adjuvant chemotherapy is standard of care for radically resected stage III
colon cancer and an accepted option for high-risk stage II. Two recent retrospective studies …