TGF-β is an immunoregulatory protein that contributes to inadequate antitumor immune
responses in cancer patients. Recent experimental data suggests that TGF-β inhibition …

A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-
2) may boost the immune system to fight tumors. CD4+ T cells, the cells that orchestrate the …

Complete clinical regressions of solid tumors in response to chemotherapy are difficult to
explain by direct cytotoxicity alone, because of low growth fractions and obstacles to drug …

Purpose: Transforming growth factor-β (TGF-β) is an immunosuppressive cytokine, having
direct suppressive activity against conventional CD4+ and CD8+ T cells and natural killer …

In this paper a mathematical model is presented that describes growth, immune escape, and
siRNA treatment of tumors. The model consists of a system of nonlinear, ordinary differential …

T-cell mediated immunotherapy for malignant diseases has become an effective treatment
option, especially in malignant melanoma. Recent advances have enabled the transfer of …

This article will introduce a novel concept in the use of TGF-β insensitive host immune cells
in cancer therapy. TGF-β is a multi-functional cytokine. At a cellular level, it mediates cellular …

In this paper we develop a new mathematical model of immunotherapy and cancer
vaccination, focusing on the role of antigen presentation and co-stimulatory signaling …

Introduction: Malignant tumors often escape surveillance and eventual destruction by the
host immune system through a variety of strategies including production of transforming …

We develop a mathematical model to examine the role of helper and cytotoxic T cells in an
anti-tumour immune response. The model comprises three ordinary differential equations …