Causal associations between gut microbiota and sepsis: A two‐sample Mendelian randomization study

J You, X Bi, K Zhang, D Xie, Y Chai… - European Journal of …, 2023 - Wiley Online Library
Background Targeting the gut microbiota may become a new therapeutic to prevent and
treat sepsis. Nonetheless, the causal relationship between specific intestinal flora and …

Causal effects of gut microbiota on sepsis: a two-sample Mendelian randomization study

JH Chen, LY Zeng, YF Zhao, HX Tang, H Lei… - Frontiers in …, 2023 - frontiersin.org
Background Recent studies had provided evidence that the gut microbiota is associated with
sepsis. However, the potential causal relationship remained unclear. Methods The present …

The causality of gut microbiota on onset and progression of sepsis: a bi-directional Mendelian randomization analysis

Y Gao, L Liu, Y Cui, J Zhang, X Wu - Frontiers in Immunology, 2024 - frontiersin.org
Background Several observational studies have proposed a potential link between gut
microbiota and the onset and progression of sepsis. Nevertheless, the causality of gut …

Gut microbiota and sepsis: bidirectional Mendelian study and mediation analysis

Z Zhang, L Cheng, D Ning - Frontiers in Immunology, 2023 - frontiersin.org
Background There is a growing body of evidence that suggests a connection between the
composition of gut microbiota and sepsis. However, more research is needed to better …

Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing …

S Yang, J Guo, Z Kong, M Deng, J Da, X Lin… - Journal of Translational …, 2024 - Springer
Background Gut microbiota alterations have been implicated in sepsis and related infectious
diseases, but the causal relationship and underlying mechanisms remain unclear. Methods …

Gut microbiota and sepsis and sepsis-related death: a Mendelian randomization investigation

W Shang, S Zhang, H Qian, S Huang, H Li… - Frontiers in …, 2024 - frontiersin.org
Background It is unclear what the causal relationship is between the gut microbiota and
sepsis. Therefore, we employed Mendelian randomization (MR) to determine whether a …

Causal relationship between gut microbiota and puerperal sepsis: a 2-sample Mendelian randomization study

L Liang, S Li, M Huang, H Peng, Z Lu, Z Zhang… - Frontiers in …, 2024 - frontiersin.org
Background Some recent observational studies have shown that gut microbiota composition
is associated with puerperal sepsis (PS) and no causal effect have been attributed to this …

Gut microbiome features are associated with sepsis onset and outcomes

K Rao, AR Patel, AM Seekatz, CM Bassis, Y Sun… - Biorxiv, 2021 - biorxiv.org
Background Epidemiologic studies have linked antibiotic exposure to subsequent sepsis,
suggesting that microbiome disruption may be in the causal pathway and an independent …

The causal relationship between gut microbiota and nine infectious diseases: a two-sample Mendelian randomization analysis

S Wang, F Yin, W Sun, R Li, Z Guo, Y Wang… - Frontiers in …, 2024 - frontiersin.org
Background Evidence from observational studies and clinical trials has associated gut
microbiota with infectious diseases. However, the causal relationship between gut …

Gut microbiota composition and changes in patients with sepsis: potential markers for predicting survival

F Luan, Y Zhou, X Ma, Y Li, Y Peng, X Jia, N Li… - BMC microbiology, 2024 - Springer
Background Sepsis can cause immune dysregulation and multiple organ failure in patients
and eventually lead to death. The gut microbiota has demonstrated its precise therapeutic …