Background Current guidelines target low-density lipoprotein cholesterol (LDL-C)
concentrations to reduce atherosclerotic cardiovascular disease (ASCVD) risk, and yet …

Background It is uncertain whether pharmacological reductions in very‐low‐density
lipoproteins (VLDLs), and their component triglyceride and cholesterol could reduce …

There is an urgent need for future randomized clinical intervention trials examining whether
lowering remnant cholesterol and triglycerides in those with high concentrations can reduce …

Objectives: This study sought to assess the contribution of low-density lipoprotein (LDL)–
dependent and LDL–independent effects of LDL-lowering therapies to changes in C …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Abstract Aims Lipoprotein (a)(Lp (a)) elevation is a causal risk factor for cardiovascular
disease (CVD). It has however been suggested that elevated Lp (a) causes CVD mainly in …

An elevated serum level of LDL cholesterol is a well-known risk factor for cardiovascular
disease (CVD), but the role of elevated triglyceride levels is debated. Controversies …

Abstract Purpose of Review Implementation of intensive LDL cholesterol (LDL-C) lowering
strategies and recognition of the role of triglyceride-rich lipoproteins (TRL) in atherosclerosis …

Importance Although lipoprotein (a)(Lp [a]) is a causal genetic risk factor for atherosclerotic
cardiovascular disease, it remains unclear which patients with established atherosclerotic …

BACKGROUND: Most clinicians recognize the importance of reducinglow-density
lipoprotein cholesterol (LDL-C) and, therefore, address thistherapeutic need to decrease …