The immune effector mechanisms involved in protecting against severe COVID-19 infection
in elderly nursing home residents following vaccination or natural infection are not well …

Immunosenescence may impact the functionality and breadth of vaccine-elicited humoral
immune responses. The ability of sera to neutralize the SARS-CoV-2 spike protein (S) from …

Background. Several Canadian provinces are extending the interval between COVID-19
vaccine doses to increase population vaccine coverage more rapidly. However …

Background Nursing home (NH) residents have borne a disproportionate share of SARS-
CoV-2 morbidity and mortality. Vaccines have limited hospitalisation and death from earlier …

High COVID-19 mortality among nursing home (NH) residents led to their prioritization for
SARS-CoV-2 vaccination; most NH residents received BNT162b2 mRNA vaccination under …

We examined whether the second monovalent SARS-CoV-2 mRNA booster increased
antibody levels and their neutralizing activity to Omicron variants in nursing home residents …

Nursing home (NH) residents have experienced significant morbidity and mortality to SARS-
CoV-2 throughout the pandemic. Vaccines initially curbed NH resident morbidity and …

The SARS-CoV-2 pandemic impact on nursing home (NH) residents prompted their
prioritization for early vaccination. To fill the data gap for vaccine immunogenicity in NH …

The emergence of SARS-CoV-2 Omicron variant (B. 1.1. 529) with major spike protein
mutations has raised concern over potential neutralization escape and breakthrough …

Background SARS-CoV-2 vaccination is the most effective strategy to protect older residents
of long-term care facilities (LTCF) against severe COVID-19, but primary vaccine responses …