Purpose: To evaluate the effect of theacrine on sepsis progression and sepsis-induced lung
injury and its mechanism of action. Methods: Lung injury model of lipopolysaccharide (LPS) …

Acute kidney injury (AKI) is a frequent and serious complication of sepsis, which results in a
rapid decline of kidney function. Currently, there are no curative therapies for AKI. Theacrine …

The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of
patients. The efficacy of current treatment strategies is low as treatment is usually initiated …

Sepsis, a common critical disease, has high morbidity and mortality. Acute lung injury (ALI)
is one of the important complications of sepsis, its effective treatment measures remain …

Sepsis is caused by the inadequate response to infection and may eventually lead to fatal
organ dysfunction and a high mortality rate. Acute lung injury (ALI) caused by sepsis is an …

The present study demonstrates the effect of rubriflordilactone on lipopolysaccharide (LPS)-
induced acute kidney injury in rats and MLE-15 cells. LPS administration in rats resulted in …

Background Acute lung injury (ALI) is a severe disease that can lead to acute respiratory
distress syndrome (ARDS), characterized by intractable hypoxemia, poor lung compliance …

Chrysin, a natural polyphenol plentifully contained in honey, propolis, vegetables and fruits,
it has been reported to exert a variety of pharmacological activities. In the present study, we …

Objectives This study was designed to investigate the effects and the mechanism of
Tanshinone IIA (TIIA) on endotoxic shock-induced lung injury in a mouse model. Methods …

Background The inappropriate apoptosis of macrophages plays an important role in the
pathogenesis of sepsis-induced acute lung injury, however, the detailed regulatory …