Long-term outcomes following CAR T cell therapy: what we know so far

KM Cappell, JN Kochenderfer - Nature reviews Clinical oncology, 2023 - nature.com
Chimeric antigen receptors (CAR) are engineered fusion proteins designed to target T cells
to antigens expressed on cancer cells. CAR T cells are now an established treatment for …

Chimeric antigen receptor-modified T cell therapy in multiple myeloma: beyond B cell maturation antigen

M Timmers, G Roex, Y Wang… - Frontiers in …, 2019 - frontiersin.org
Chimeric antigen receptor (CAR)-modified T cell therapy is a rapidly emerging
immunotherapeutic approach that is revolutionizing cancer treatment. The impressive …

Overview of approved CAR‐T therapies, ongoing clinical trials, and its impact on clinical practice

S Sengsayadeth, BN Savani, O Oluwole, B Dholaria - EJHaem, 2022 - Wiley Online Library
In recent years, we have seen rapid expansion of chimeric antigen receptor T‐cell (CAR‐T)
therapies in multiple malignancies. CAR‐T therapy has profoundly altered the treatment …

CAR T‐cell therapy in hematologic malignancies: a voyage in progress

SA Holstein, MA Lunning - Clinical Pharmacology & …, 2020 - Wiley Online Library
The development of chimeric antigen receptor (CAR) T‐cell therapy for select hematological
malignancies represents one of the most remarkable therapeutic advances in the past …

Bispecific chimeric antigen receptor T cell therapy for B cell malignancies and multiple myeloma

RJ Cronk, J Zurko, NN Shah - Cancers, 2020 - mdpi.com
Simple Summary In relapsed, refractory B cell malignancies and multiple myeloma, chimeric
antigen receptor (CAR) T cell therapy has represented a major scientific advancement with …

A phase 1, open-label study of LCAR-B38M, a chimeric antigen receptor T cell therapy directed against B cell maturation antigen, in patients with relapsed or …

WH Zhao, J Liu, BY Wang, YX Chen, XM Cao… - Journal of hematology & …, 2018 - Springer
Background Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven
efficacy in some hematologic cancers. We evaluated the safety and efficacy of LCAR-B38M …

CAR T cell therapy of non-hematopoietic malignancies: detours on the road to clinical success

KB Long, RM Young, AC Boesteanu… - Frontiers in …, 2018 - frontiersin.org
Chimeric antigen receptor (CAR)-engineered T cells represent a breakthrough in
personalized medicine. In this strategy, a patient's own T lymphocytes are genetically …

CAR T-cell therapy for patients with multiple myeloma: current evidence and challenges

MJ Rendo, JJ Joseph, LM Phan… - Blood and lymphatic …, 2022 - Taylor & Francis
The therapeutic landscape of multiple myeloma (MM) has benefited from an emergence of
novel therapies over the last decade. By inducing T-cell kill of target cancer cells, chimeric …

[HTML][HTML] Chimeric antigen receptor-T-cell therapy for B-cell hematological malignancies: an update of the pivotal clinical trial data

G Roex, T Feys, Y Beguin, T Kerre, X Poiré, P Lewalle… - Pharmaceutics, 2020 - mdpi.com
Chimeric antigen receptor (CAR)-T-cell therapy is an innovative form of adoptive cell therapy
that has revolutionized the treatment of certain hematological malignancies, including B-cell …

[HTML][HTML] Durable clinical responses in heavily pretreated patients with relapsed/refractory multiple myeloma: updated results from a multicenter study of bb2121 anti …

JG Berdeja, Y Lin, N Raje, N Munshi, D Siegel… - Blood, 2017 - Elsevier
Introduction: Chimeric antigen receptor (CAR) T cell therapies have demonstrated robust
and sustained clinical responses in several hematologic malignancies. Data suggest that …