Comparative genomics reveals distinct immune-oncologic pathways in African American men with prostate cancer

S Awasthi, A Berglund, J Abraham-Miranda… - Clinical Cancer …, 2021 - AACR
Purpose: The role of immune-oncologic mechanisms of racial disparities in prostate cancer
remains understudied. Limited research exists to evaluate the molecular underpinnings of …

Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences

W Rayford, AT Beksac, J Alger, M Alshalalfa… - Communications …, 2021 - nature.com
Racial disparities in prostate cancer have not been well characterized on a genomic level.
Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 …

Tumor immunobiological differences in prostate cancer between African-American and European-American men

TA Wallace, RL Prueitt, M Yi, TM Howe, JW Gillespie… - Cancer research, 2008 - AACR
The incidence and mortality rates of prostate cancer are significantly higher in African-
American men when compared with European-American men. We tested the hypothesis that …

Racial disparity in prostate cancer in the African American population with actionable ideas and novel immunotherapies

ZS Dovey, SS Nair, D Chakravarty, AK Tewari - Cancer reports, 2021 - Wiley Online Library
Abstract Background African Americans (AAs) in the United States are known to have a
higher incidence and mortality for Prostate Cancer (PCa). The drivers of this epidemiological …

[HTML][HTML] Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters

M Linch, G Goh, C Hiley, Y Shanmugabavan… - Annals of …, 2017 - Elsevier
Background Intratumoural heterogeneity (ITH) is well recognised in prostate cancer (PC),
but its role in high-risk disease is uncertain. A prospective, single-arm, translational study …

Copy number and gene expression differences between African American and Caucasian American prostate cancer

AE Rose, JM Satagopan, C Oddoux, Q Zhou… - Journal of translational …, 2010 - Springer
Background The goal of our study was to investigate the molecular underpinnings
associated with the relatively aggressive clinical behavior of prostate cancer (PCa) in African …

Genomic, epigenomic, and transcriptomic signatures of prostate cancer between African American and European American patients

C Stevens, A Hightower, SG Buxbaum… - Frontiers in …, 2023 - frontiersin.org
Prostate cancer is the second most common cancer in men in the United States, and racial
disparities are greatly observed in the disease. Specifically, African American (AA) patients …

Elevation of stromal-derived mediators of inflammation promote prostate cancer progression in African-American men

M Gillard, R Javier, Y Ji, SL Zheng, J Xu, CB Brendler… - Cancer research, 2018 - AACR
Progress in prostate cancer racial disparity research has been hampered by a lack of
appropriate research tools and better understanding of the tumor biology. Recent gene …

Novel biomarker signature that may predict aggressive disease in African American men with prostate cancer

K Yamoah, MH Johnson, V Choeurng… - Journal of Clinical …, 2015 - ascopubs.org
Purpose We studied the ethnicity-specific expression of prostate cancer (PC)–associated
biomarkers to evaluate whether genetic/biologic factors affect ethnic disparities in PC …

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

DN Rodrigues, P Rescigno, D Liu… - The Journal of …, 2018 - Am Soc Clin Investig
BACKGROUND. Understanding the integrated immunogenomic landscape of advanced
prostate cancer (APC) could impact stratified treatment selection. METHODS. Defective …