Disturbance Observer-Based PID Control System Using DNA Strand Displacement and Its Application in Exponential Gate

W Zhang, H Lv - IEEE Access, 2023 - ieeexplore.ieee.org
Synthetic control circuits have demonstrated their effectiveness in molecular process control.
However, current synthetic control circuits counteract the impact of disturbances by error …

DNA strand displacement reactions to accomplish a two-degree-of-freedom PID controller and its application in subtraction gate

Y Yuan, H Lv, Q Zhang - IEEE Transactions on NanoBioscience, 2021 - ieeexplore.ieee.org
Synthesis control circuits can be used to effectively control biochemical molecule processes.
In the controller design based on chemical reaction networks (CRNs), generally only the …

[HTML][HTML] The design of 2DOF IMC-PID controller in biochemical reaction networks

Y Li, H Lv, X Wang - Applied Sciences, 2023 - mdpi.com
DNA molecules can be adopted to design biomolecular control circuits that can effectively
control biochemical reaction processes. However, the leak reaction in actual biochemical …

Biologically inspired design of feedback control systems implemented using DNA strand displacement reactions

M Foo, R Sawlekar, VV Kulkarni… - 2016 38th Annual …, 2016 - ieeexplore.ieee.org
The use of abstract chemical reaction networks (CRNs) as a modelling and design
framework for the implementation of computing and control circuits using enzyme-free …

Cascade PID Control Systems Based on DNA Strand Displacement With Application in Polarization of Tumor-Associated Macrophages

H Xue, H Lv, Y Xiao - IEEE Access, 2023 - ieeexplore.ieee.org
Disturbances are widespread in biochemical systems. Nowadays, prevalent single-loop
control strategies only take external disturbances into account. However, internal …

Robustness analysis of DNA-based biomolecular feedback controllers to parametric and time delay uncertainties

R Sawlekar, M Foo, DG Bates - 2016 IEEE Biomedical Circuits …, 2016 - ieeexplore.ieee.org
Recent advances in DNA computing have greatly facilitated the design of bimolecular
circuitry based on DNA strand displacement reactions. An important issue to consider in the …

Implementation of an Ultrasensitive Biomolecular Controller for Enzymatic Reaction Processes With Delay Using DNA Strand Displacement

Y Xiao, H Lv - IEEE Transactions on NanoBioscience, 2023 - ieeexplore.ieee.org
In this article, a set of abstract chemical reactions has been employed to construct a novel
nonlinear biomolecular controller, ie, the Brink controller (BC) with direct positive …

PID and state feedback controllers using DNA strand displacement reactions

NMG Paulino, M Foo, J Kim… - IEEE Control Systems …, 2019 - ieeexplore.ieee.org
Nucleic acid-based chemistry is a strong candidate framework for the construction of future
synthetic biomolecular control circuits. Previous work has demonstrated the capacity of …

PID control of biochemical reaction networks

M Whitby, L Cardelli, M Kwiatkowska… - … on Automatic Control, 2021 - ieeexplore.ieee.org
Principles of feedback control have been shown to naturally arise in biological systems and
have been applied with success to build synthetic circuits. Here, we present an …

Analysis of finite-time regulation property of biomolecular PI controller

P Rong, T Nakakuki - Control Theory and Technology, 2020 - Springer
In practical applications of dynamic DNA nanotechnology, a biomolecular controller is
required for maintaining the operation of the molecular actuator at a desired condition based …