Collider bias undermines our understanding of COVID-19 disease risk and severity

GJ Griffith, TT Morris, MJ Tudball, A Herbert… - Nature …, 2020 - nature.com
Numerous observational studies have attempted to identify risk factors for infection with
SARS-CoV-2 and COVID-19 disease outcomes. Studies have used datasets sampled from …

How to detect and reduce potential sources of biases in studies of SARS-CoV-2 and COVID-19

EK Accorsi, X Qiu, E Rumpler… - European Journal of …, 2021 - Springer
In response to the coronavirus disease (COVID-19) pandemic, public health scientists have
produced a large and rapidly expanding body of literature that aims to answer critical …

Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank

CL Niedzwiedz, CA O'Donnell, BD Jani, E Demou… - BMC medicine, 2020 - Springer
Background Understanding of the role of ethnicity and socioeconomic position in the risk of
developing SARS-CoV-2 infection is limited. We investigated this in the UK Biobank study …

Ethnicity, comorbidity, socioeconomic status, and their associations with COVID-19 infection in England: a cohort analysis of UK Biobank data

A Prats-Uribe, R Paredes, D Prieto-Alhambra - MedRxiv, 2020 - medrxiv.org
Background Recent data suggest higher COVID-19 rates and severity in Black, Asian, and
minority ethnic (BAME) communities. We aimed to study the association between ethnicity …

Risk factors for positive and negative COVID-19 tests: a cautious and in-depth analysis of UK biobank data

M Chadeau-Hyam, B Bodinier, J Elliott… - International journal …, 2020 - academic.oup.com
Background The recent COVID-19 outbreak has generated an unprecedented public health
crisis, with millions of infections and hundreds of thousands of deaths worldwide. Using …

Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies

S Luo, Y Liang, THT Wong… - International journal …, 2022 - academic.oup.com
Background To summarize modifiable factors for coronavirus disease 2019 (COVID-19)
suggested by Mendelian randomization studies. Methods In this systematic review, we …

Don't blame the BAME: Ethnic and structural inequalities in susceptibilities to COVID‐19

GR Bentley - American journal of human biology, 2020 - Wiley Online Library
One of the striking features emerging from the COVID-19 pandemic has been the early
recognition of ethnic disparities in both vulnerability to contracting the disease, as well as its …

Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank

DA Kolin, S Kulm, PJ Christos, O Elemento - PLoS One, 2020 - journals.plos.org
Background Coronavirus disease 2019 (Covid-19) has rapidly infected millions of people
worldwide. Recent studies suggest that racial minorities and patients with comorbidities are …

How many are at increased risk of severe COVID-19 disease? Rapid global, regional and national estimates for 2020

A Clark, M Jit, C Warren-Gash, B Guthrie, HHX Wang… - MedRxiv, 2020 - medrxiv.org
Background The risk of severe COVID-19 disease is known to be higher in older individuals
and those with underlying health conditions. Understanding the number of individuals at …

Cardiometabolic risk factors for COVID-19 susceptibility and severity: a Mendelian randomization analysis

A Leong, JB Cole, LN Brenner, JB Meigs… - PLoS …, 2021 - journals.plos.org
Background Epidemiological studies report associations of diverse cardiometabolic
conditions including obesity with COVID-19 illness, but causality has not been established …