Polygenic Risk Score-Based Association Analysis Identifies Genetic Comorbidities Associated with Age-Related Hearing Difficulty in Two Independent Samples

IS Bhatt, JA Raygoza Garay, SG Bhagavan… - Journal of the …, 2024 - Springer
Purpose Age-related hearing loss is the most common form of permanent hearing loss that
is associated with various health traits, including Alzheimer's disease, cognitive decline, and …

Association of polygenic risk scores for hearing difficulty in older adults with hearing loss in mid-childhood and midlife: a population-based cross-sectional study within …

J Wang, K Lange, V Sung, A Morgan… - … –Head & Neck …, 2023 - jamanetwork.com
Importance Although more than 200 genes have been associated with monogenic
congenital hearing loss, the polygenic contribution to hearing decline across the life course …

GWAS identifies 44 independent associated genomic loci for self-reported adult hearing difficulty in UK Biobank

HRR Wells, MB Freidin, FNZ Abidin, A Payton… - The American Journal of …, 2019 - cell.com
Age-related hearing impairment (ARHI) is the most common sensory impairment in the
aging population; a third of individuals are affected by disabling hearing loss by the age of …

Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment

E Fransen, S Bonneux, JJ Corneveaux… - European Journal of …, 2015 - nature.com
We performed a genome-wide association study (GWAS) to identify the genes responsible
for age-related hearing impairment (ARHI), the most common form of hearing impairment in …

Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty

G Kalra, B Milon, AM Casella, BR Herb… - PLoS …, 2020 - journals.plos.org
Age-related hearing impairment (ARHI), one of the most common medical conditions, is
strongly heritable, yet its genetic causes remain largely unknown. We conducted a meta …

A large genome-wide association study of age-related hearing impairment using electronic health records

TJ Hoffmann, BJ Keats, N Yoshikawa, C Schaefer… - PLoS …, 2016 - journals.plos.org
Age-related hearing impairment (ARHI), one of the most common sensory disorders, can be
mitigated, but not cured or eliminated. To identify genetic influences underlying ARHI, we …

Self-reported hearing loss questions provide a good measure for genetic studies: a polygenic risk score analysis from UK Biobank

SS Cherny, G Livshits, HRR Wells, MB Freidin… - European Journal of …, 2020 - nature.com
Age-related hearing impairment (ARHI) is very common in older adults and has major
impact on quality of life. The heritability of ARHI has been estimated to be around 50%. The …

Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank

MA Lewis, BA Schulte, JR Dubno, KP Steel - BMC biology, 2022 - Springer
Background Age-related hearing loss is a common, heterogeneous disease with a strong
genetic component. More than 100 loci have been reported to be involved in human hearing …

Polygenic risk score-based association analysis of speech-in-noise and hearing threshold measures in healthy young adults with self-reported normal hearing

IS Bhatt, SK Ramadugu, S Goodman… - Journal of the …, 2023 - Springer
Purpose Speech-in-noise (SIN) traits exhibit high inter-subject variability, even for healthy
young adults reporting normal hearing. Emerging evidence suggests that genetic variability …

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment

AP Nagtegaal, L Broer, NR Zilhao, J Jakobsdottir… - Scientific reports, 2019 - nature.com
Previous research has shown that genes play a substantial role in determining a person's
susceptibility to age-related hearing impairment. The existing studies on this subject have …