Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …

Background Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal
fibrotic disorder, with no curative therapies. The signal transducer and activator of …

Pulmonary hypertension is defined as a group of diseases characterized by a progressive
increase in pulmonary vascular resistance (PVR), which leads to right ventricular failure and …

There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lung, most
commonly resulting from cigarette smoke exposure, characterised by a largely irreversible …

Idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis‐associated interstitial lung
disease (RA‐ILD) are two fibrotic interstitial lung diseases that share the usual interstitial …

The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Background: JAK/STAT signal pathway, a requisite part in the signaling process of growth
factors and cytokines, has become attractive targets for numerous immune, inflammatory …

Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic
pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators …