Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter
its morphology and function in response to stimuli in its surrounding environment. The ability …

The human skeleton is a miracle of engineering, combining both toughness and light weight.
It does so because bones possess cellular mechanisms wherein external mechanical loads …

Proper development of the skeleton in utero and during growth requires mechanical
stimulation. Loading results in adaptive changes in bone that strengthen bone structure …

Osteoblasts are key components of the bone multicellular unit and have a seminal role in
bone remodeling, which is an essential function for the maintenance of the structural …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

Bone is a dynamic tissue that is constantly renewed. The cell populations that participate in
this process—the osteoblasts and osteoclasts—are derived from different progenitor pools …

Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment.
Increases in strain lead to increased bone mass acquisition, whereas decreases in strain …

Mechanotransduction is pivotal in the maintenance of homeostasis in different tissues and
involves multiple cell signaling pathways. In bone, mechanical stimuli regulate the balance …

Mechanical stimulation has a critical role in the development and maintenance of the
skeleton. This function requires the perception of extracellular stimuli as well as their …