Immunothrombosis—immune-mediated activation of coagulation—is protective against
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …

Coronavirus disease 2019 (COVID-19) is the most devastating infectious disease in the 21st
century with more than 2 million lives lost in less than a year. The activation of …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …

NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) inflammasome has recently
become an intriguing target of several chronic and viral diseases. Here, we argue that …

Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …

Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by respiratory
failure, shock or multiorgan dysfunction, often accompanied by systemic hyperinflammation …

Abstract SARS‐CoV‐2 triggers inflammasome‐dependent release of pro‐inflammatory
cytokine IL‐1β and pyroptosis, therefore, contributes to the huge inflammatory response …