The nanocatalytic activity of nanozymes provides a vision for tumor treatment. However, the
glutathione (GSH)-related antioxidant defense system (ADS) formed on the basis of …

Nanocatalytic medicine has been developed recently to trigger intratumoral generation of
highly toxic reactive oxygen species (ROS) for cancer therapy, which, unfortunately, suffers …

Although nanocatalytic therapy has become an emerging strategy for tumor treatment, the
therapeutic effects of reactive oxygen species (ROS)-mediated treatment are still seriously …

Chemodynamic therapy represents a distinct anti-tumor strategy by activating intratumoral
chemical catalytic reactions to produce highly toxic reactive oxygen species (ROS) from non …

Emerging cancer cell ferroptosis features the direct depletion of glutathione (GSH) and
resultant chemical inhibition on glutathione peroxidase 4 (GPX4) bioactivity, which …

Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an
emerging technology for therapeutic treatment of various malignant tumors. However, the …

Catalytic cascade transformations, which occur in spatially constrained tumor environment to
generate therapeutic moieties from prodrugs or intrinsic species, are highly desirable for …

Hypoxia has been firmly correlated to the drug resistance of solid tumors. Alleviation of
hypoxia by tumor reoxygenation is expected to sensitize the chemotherapy toward solid …

Ferroptosis, a cell death path induced by the generation of reactive oxygen species (ROS),
will cause the accumulation of lipid peroxides (PL-PUFA-OOH) and achieve potent tumor …

Nanomaterials with shifting or mixed redox states is one of the most common studied
nanozyme with peroxidase-like activity for chemodynamic therapy (CDT), which can …