Mesenchymal stem cells (MSC s) hold profound promise in tissue repair/regeneration.
However, MSC s undergo remarkable spontaneous differentiation and aging during …

Mesenchymal stem cells (MSCs) exhibit self-renewal, multi-lineage differentiation potential
and immunomodulatory properties, and are promising candidates for cellular therapy of …

Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic
tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these …

While traditional cell culture methods have relied on growing cells as monolayers, three-
dimensional (3D) culture systems can provide a convenient in vitro model for the study of …

Multipotent mesenchymal stem cells (MSCs) are one of the most powerful tools in
regeneration medicine. Their low differentiation efficiency, however, limits further application …

Abstract Three‐dimensional (3D) culture has been shown to improve pluripotent gene
expression in mesenchymal stem cells (MSC s), but the underlining mechanisms were …

Abstract Background Three-dimensional (3D) multicellular spheroids of mesenchymal stem
cells (MSCs) are generally regarded to have beneficial properties over MSCs in monolayer …

The aim of our work was to develop a protocol enabling a derivation of mesenchymal
stem/stromal cell (MSC) subpopulation with increased expression of pluripotent and neural …

Mesenchymal stem/stromal cells (MSCs) are multipotent and self-renewal cells that are
widely used in regenerative medicine. The culture of three-dimensional (3D) spheroid MSCs …

Compared with traditional 2D adherent cell culture, 3D spheroidal cell aggregates, or
spheroids, are regarded as more physiological, and this technique has been exploited in the …