[PDF][PDF] Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development
The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
[PDF][PDF] Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition
We previously used single-cell transcriptomic analysis to characterize human fetal retinal
development and assessed the degree to which retinal organoids recapitulate normal …
development and assessed the degree to which retinal organoids recapitulate normal …
[PDF][PDF] Molecular anatomy of the developing human retina
Clinical and genetic heterogeneity associated with retinal diseases makes stem-cell-based
therapies an attractive strategy for personalized medicine. However, we have limited …
therapies an attractive strategy for personalized medicine. However, we have limited …
[PDF][PDF] Single-cell transcriptomic comparison of human fetal retina, hPSC-derived retinal organoids, and long-term retinal cultures
To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …
seq) at key fetal stages and follow the development of the major cell types as well as …
Generating and using transcriptomically based retinal cell atlases
It has been known for over a century that the basic organization of the retina is conserved
across vertebrates. It has been equally clear that retinal cells can be classified into …
across vertebrates. It has been equally clear that retinal cells can be classified into …
A single‐cell transcriptome atlas of the adult human retina
The retina is a specialized neural tissue that senses light and initiates image processing.
Although the functional organization of specific retina cells has been well studied, the …
Although the functional organization of specific retina cells has been well studied, the …
Single-cell RNA sequencing in vision research: Insights into human retinal health and disease
Gene expression provides valuable insight into cell function. As such, vision researchers
have frequently employed gene expression studies to better understand retinal physiology …
have frequently employed gene expression studies to better understand retinal physiology …
[HTML][HTML] Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal
Purpose: Retinal organoids generated from human pluripotent stem cells exhibit
considerable variability during differentiation. Our goals are to assess developmental …
considerable variability during differentiation. Our goals are to assess developmental …
[HTML][HTML] Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration
M Menon, S Mohammadi, J Davila-Velderrain… - Nature …, 2019 - nature.com
Genome-wide association studies (GWAS) have identified genetic variants associated with
age-related macular degeneration (AMD), one of the leading causes of blindness in the …
age-related macular degeneration (AMD), one of the leading causes of blindness in the …
[HTML][HTML] Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
Atoh7 has been believed to be essential for establishing the retinal ganglion cell (RGC)
lineage, and Pou4f2 and Isl1 are known to regulate RGC specification and differentiation …
lineage, and Pou4f2 and Isl1 are known to regulate RGC specification and differentiation …