A serological point-of-care test for the detection of IgG antibodies against Ebola virus in human survivors

P Brangel, A Sobarzo, C Parolo, BS Miller, PD Howes… - ACS …, 2018 - ACS Publications
Ebola virus disease causes widespread and highly fatal epidemics in human populations.
Today, there is still great need for point-of-care tests for diagnosis, patient management and …

Towards detection and diagnosis of Ebola virus disease at point-of-care

A Kaushik, S Tiwari, RD Jayant, A Marty… - Biosensors and …, 2016 - Elsevier
Ebola outbreak-2014 (mainly Zaire strain related Ebola virus) has been declared most
widely spread deadly persistent epidemic due to unavailability of rapid diagnostic, detection …

A point-of-care diagnostic for differentiating Ebola from endemic febrile diseases

D Sebba, AG Lastovich, M Kuroda, E Fallows… - Science translational …, 2018 - science.org
Hemorrhagic fever outbreaks such as Ebola are difficult to detect and control because of the
lack of low-cost, easily deployable diagnostics and because initial clinical symptoms mimic …

Diagnosis of Ebola virus disease: past, present, and future

MJ Broadhurst, TJG Brooks… - Clinical microbiology …, 2016 - Am Soc Microbiol
Laboratory diagnosis of Ebola virus disease plays a critical role in outbreak response efforts;
however, establishing safe and expeditious testing strategies for this high-biosafety-level …

Development and evaluation of a fluorogenic 5′ nuclease assay to detect and differentiate between Ebola virus subtypes Zaire and Sudan

TR Gibb, DA Norwood Jr, N Woollen… - Journal of Clinical …, 2001 - Am Soc Microbiol
The ability to rapidly recognize Ebola virus infections is critical to quickly limit further spread
of the disease. A rapid, sensitive, and specific laboratory diagnostic test is needed to confirm …

Performance of the GeneXpert Ebola assay for diagnosis of Ebola virus disease in Sierra Leone: a field evaluation study

AE Semper, MJ Broadhurst, J Richards… - PLoS …, 2016 - journals.plos.org
Background Throughout the Ebola virus disease (EVD) epidemic in West Africa, field
laboratory testing for EVD has relied on complex, multi-step real-time reverse transcription …

Detection of Ebola viral antigen by enzyme-linked immunosorbent assay using a novel monoclonal antibody to nucleoprotein

M Niikura, T Ikegami, M Saijo, I Kurane… - Journal of clinical …, 2001 - Am Soc Microbiol
With the increase in international traffic, the risk of introducing rare but severe infectious
diseases like Ebola hemorrhagic fever is increasing all over the world. However, the system …

Discovery of an antibody for pan-ebolavirus therapy

W Furuyama, A Marzi, A Nanbo, E Haddock… - Scientific reports, 2016 - nature.com
During the latest outbreak of Ebola virus disease in West Africa, monoclonal antibody
therapy (eg, ZMapp) was utilized to treat patients. However, due to the antigenic differences …

[HTML][HTML] Evaluation of a point-of-care blood test for identification of Ebola virus disease at Ebola holding units, Western Area, Sierra Leone, January to February 2015

NF Walker, CS Brown, D Youkee, P Baker… - …, 2015 - eurosurveillance.org
Current Ebola virus disease (EVD) diagnosis relies on reverse transcription-PCR (RT-PCR)
technology, requiring skilled laboratory personnel and technical infrastructure. Lack of …

[PDF][PDF] Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection

AI Flyak, X Shen, CD Murin, HL Turner, JA David… - Cell, 2016 - cell.com
Recent studies have suggested that antibody-mediated protection against the Ebolaviruses
may be achievable, but little is known about whether or not antibodies can confer cross …