Implementation of protocolized surveillance, diagnosis, and management of septic patients,
and of surgical sepsis patients in particular, is shown to result in significantly increased …

Improved management of severe sepsis has been one of the major health care
accomplishments of the last two decades. Due to enhanced recognition and improved …

Objective: To analyze serial biomarkers of the persistent inflammation, immunosuppression,
and catabolism syndrome (PICS) to gain insight into the pathobiology of chronic critical …

Background Hospital deaths after sepsis have decreased substantially and most young
adult survivors rapidly recover (RAP). However, many older survivors develop chronic …

Dysregulated host immune responses to infection often occur, leading to sepsis, multiple
organ failure, and death. Some patients rapidly recover from sepsis, but many develop …

Clinical and technological advances promoting early hemorrhage control and physiologic
resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly …

Background: Multiple organ dysfunction (MOD) has plagued intensive care units (ICUs) for
more than four decades, and its epidemiology has evolved because more patients are …

Introduction Sepsis is a common, costly and morbid cause of critical illness in trauma and
surgical patients. Ongoing advances in sepsis resuscitation and critical care support …

Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the
experienced intensivist as a “complicated clinical course” and is frequently attributed to …

BACKGROUND A growing number of patients survive sepsis but remain chronically critically
ill. We sought to define clinical outcomes and incidence of chronic critical illness (CCI) after …