Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory
mechanisms have evolved to maintain iron homeostasis within cells and between different …

The mitochondrion is well known for its key role in energy transduction. However, it is less
well appreciated that it is also a focal point of iron metabolism. Iron is needed not only for …

Maintenance of proper “labile iron” levels is a critical component in preserving homeostasis.
Iron is a vital element that is a constituent of a number of important macromolecules …

It is well known that iron (Fe) is transported to the mitochondrion for heme synthesis.
However, only recently has the importance of this organelle for many other facets of Fe …

BACKGROUND: Iron is an essential element for life, as it is a cofactor for enzymes involved
in many metabolic processes, but it can also be harmful, since its excess is thought to …

Iron plays an essential role in cellular metabolism and biological processes. However, due
to its intrinsic redox activity, free iron is a potentially toxic molecule in cellular biochemistry …

Mammalian iron homeostasis must be meticulously regulated so that this essential element
is available for use, but at the same time prevented from promoting the formation of toxic …

Iron is indispensable for the growth, development and well-being of almost all living
organisms. Biological systems from bacteria, fungi and plants to humans have evolved …