While interleukin-5 (IL-5) is initially identified by its ability to support the growth and terminal
differentiation of mouse B cells in vitro into antibody-secreting cells, recombinant IL-5 exerts …

Extensive clinical investigations have implicated eosinophils in the pathogenesis of asthma.
In a recent clinical trial, humanized monoclonal antibody to interleukin (IL)-5 significantly …

Eosinophils have been suggested to be part of the pathologic process that characterizes
asthma, and their recruitment into the upper or lower airways appears to be essential for the …

T helper 2 cells produce a number of cytokines including inteleukin (IL)-5, IL-4 and IL-13.
Group 2 innate lymphoid cells (ILC2s) also produce IL-5 under sterile conditions. IL-5 is …

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation
and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective …

Abstract Interleukin-9 (IL-9) has been implicated in the pathogenesis of allergic disorders. To
examine the interaction between IL-9 and eosinophils, we evaluated mature peripheral …

Descriptive studies have shown an association between eosinophils, interleukin (IL)-5 and
pathophysiological processes in patients with atopic asthma. These observations have led …

Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-
secreting cells as well as inducing the growth of Ly-1 (CD5)+ B cells and B-cell tumors. It …

Interleukin‐5 is a Th2 homodimeric cytokine involved in the differentiation, maturation,
migration, development, survival, trafficking and effector function of blood and local tissue …

The effects of recombinant human (rh) interleukin(IL)-4 or rhIL-13 on survival, and
chemotactic activity of humaneosinophils were examined. OnlyrhIL-13 prolonged eosinophil …