Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Cell–cell interactions define a quintessential aspect of multicellular development. Metazoan
morphogenesis depends on a handful of fundamental, conserved cellular interaction …

Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

Notch signaling has been implicated in a wide variety of processes from cell-fate decisions,
tissue patterning and morphogenesis to human diseases and cancer. A model for Notch …

Notch signaling controls numerous cell-fate specification events in multicellular organisms,
and dysregulated Notch signaling causes several diseases with underlying developmental …

Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although
the 'canonical'Notch pathway and its core members are well established–involving ligand …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Our intention here is to provide an overview of the involvement of Notch …

The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Notch signaling is a highly conserved signal transduction pathway that regulates stem cell
maintenance and differentiation in several organ systems. Upon activation, the Notch …