Metabolic syndrome (MS) is associated with both cardiovascular and bladder dysfunction.
Insulin resistance (IR) and central obesity, in particular, are the main risk factors. In these …

Despite existing therapy, patients with heart failure (HF) experience substantial morbidity
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …

Context Postprandial hyperglycemia increases systemic inflammation and is a risk factor for
cardiovascular disease. A ketone monoester (KME) drink containing β-hydroxybutyrate (β …

Hypertension is the most important risk factor for the development of terminal cardiovascular
diseases, such as heart failure, chronic kidney disease, and atherosclerosis. Lifestyle …

The ketogenic diet (KD), a high-fat, low-carbohydrate dietary approach that is based on the
induction of extensive ketone bodies (KB) metabolism, is recently receiving a lot of attention …

Diabetes is a rapidly expanding epidemic projected to affect as many as 1 in 3 Americans by
2050. This disease is characterized by devastating complications brought about high …

Metabolic perturbations underlie a variety of cardiovascular disease states; yet, metabolic
interventions to prevent or treat these disorders are sparse. Ketones carry a negative clinical …

β-Hydroxybutyrate (βOHB) is the major ketone in the body, and it is recognized as a
metabolic energy source and an important signaling molecule. While ketone oxidation is …

Ketone bodies have emerged as central mediators of metabolic health, and multiple
beneficial effects of a ketogenic diet, impacting metabolism, neuronal pathologies and, to a …

Background: The remarkable ability of the body to adapt to long-term starvation has been
critical for survival of primitive man. An appreciation of these processes can provide the …