Abstract l-Glutamate is the predominant excitatory neurotransmitter in the central nervous
system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate …

Historically, glutamate uptake in the CNS was mainly attributed to glial cells for three
reasons: 1) none of the glutamate transporters were found to be located in presynaptic …

The neurotransmitter glutamate is inactivated by cellular uptake; mostly catalyzed by the
glutamate transporter 1 (GLT1)(slc1a2, excitatory amino acid transporter [EAAT2]) subtype …

To identify glutamate transporters expressed in forebrain neurons, we prepared a cDNA
library from rat forebrain neuronal cultures, previously shown to transport glutamate with …

The L-glutamate (Glu) has been hypothesized as an excitatory amino acid neurotransmitter
in the mammalian central nervous system after successful cloning and identification of a …

The solute carrier family 1 (SLC1) is composed of five high affinity glutamate transporters,
which exhibit the properties of the previously described system XAG−, as well as two Na+ …

Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

GLT1 is the major glutamate transporter of the brain and has been thought to be expressed
exclusively in astrocytes. Although excitatory axon terminals take up glutamate, the …

Glutamate is the major excitatory neurotransmitter in the central nervous system and is
tightly regulated by cell surface transporters to avoid increases in concentration and …

GLT1, the predominant glutamate transporter of the forebrain, exists in two splice variant
isoforms, ie, GLT1a and GLT1b. Although GLT1 was originally detected only in astrocytes …