ACE2-dependent and-independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection

T Duan, C Xing, J Chu, X Deng, Y Du, X Liu, Y Hu… - Nature Cell …, 2024 - nature.com
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

LI Labzin, KY Chew, K Eschke, X Wang, T Esposito… - Science …, 2023 - science.org
Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease
caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on …

Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions

SL Yang, L DeFalco, DE Anderson, Y Zhang… - Nature …, 2021 - nature.com
SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and
RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 in cells using …

Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling

K Feng, YQ Min, X Sun, F Deng, P Li… - Journal of molecular …, 2021 - academic.oup.com
The on-going coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in unprecedented medical …

Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection

J Heuberger, J Trimpert, D Vladimirova… - EMBO molecular …, 2021 - embopress.org
Abstract SARS‐CoV‐2, the agent that causes COVID‐19, invades epithelial cells, including
those of the respiratory and gastrointestinal mucosa, using angiotensin‐converting enzyme …

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

BA Rosa, M Ahmed, DK Singh… - Communications …, 2021 - nature.com
SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the
Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 …

Manipulation of innate immune signaling pathways by SARS-CoV-2 non-structural proteins

Y Lu, HA Michel, PH Wang, GL Smith - Frontiers in Microbiology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
current coronavirus disease 2019 (COVID-19) pandemic, induces an unbalanced immune …

Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses

G Sun, Q Cui, G Garcia Jr, C Wang, M Zhang… - Scientific Reports, 2021 - nature.com
The transcriptome of SARS-CoV-2-infected cells that reflects the interplay between host and
virus has provided valuable insights into mechanisms underlying SARS-CoV-2 infection and …

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …

IL1β promotes TMPRSS2 expression and SARS-CoV-2 cell entry through the p38 MAPK-GATA2 axis

C Cioccarelli, R Sánchez-Rodríguez… - Frontiers in …, 2021 - frontiersin.org
After the outburst of the SARS-CoV-2 pandemic, a worldwide research effort has led to the
uncovering of many aspects of the COVID-19, among which we can count the outstanding …