While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …

Background Age-related changes in immune cell composition and functionality are
associated with multimorbidity and mortality. However, many centenarians delay the onset of …

Frailty is an intermediate status of the human aging process, associated with
decompensated homeostasis and death. The immune phenotype of frailty and its underlying …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Immune responses generally decline with age. However, the dynamics of this process at the
individual level have not been characterized, hindering quantification of an individual's …

Age-associated changes in immune cells have been linked to an increased risk for infection.
However, a global and detailed characterization of the changes that human circulating …

The ageing of the global population brings about unprecedented challenges. Chronic age‐
related diseases in an increasing number of people represent an enormous burden for …

Differences in immune function and responses contribute to health-and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood …

Aging is a major risk factor for several conditions including neurodegenerative,
cardiovascular diseases and cancer. Functional impairments in cellular pathways controlling …

Aging is linked to deficiencies in immune responses and increased systemic inflammation.
To unravel the regulatory programs behind these changes, we applied systems immunology …