Parkinson's disease (PD) is a neurodegenerative disease due to the degeneration of
dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is …

Liver X Receptors (LXR) alpha and beta are two members of nuclear receptor superfamily
documented as endogenous cholesterol sensors. Following conversion of cholesterol in …

Liver X receptors (LXR) are nuclear receptors that have emerged as key regulators of lipid
metabolism. In addition to their functions as cholesterol sensors, LXR have also been found …

Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and inflammation
in the central nervous system (CNS). The brain, which contains a disproportionately large …

Liver X receptors (LXRs) are nuclear receptors involved in the regulation of lipid metabolism
and inflammatory responses in the central nervous system. Defects in cholesterol …

Parkinson's disease (PD) is a neurodegenerative disease in which degeneration of
nigrostriatal neurons and inflammation are key players. The aim of our study was to analyze …

Although cholesterol is a major component of the CNS, there is little information on how or
whether a change in sterol flux across the blood–brain barrier might alter …

Liver X receptors (LXRα and LXRβ) are oxysterol receptors that function as master
transcription factors mediating cholesterol homeostasis in the periphery. LXRs regulate the …

Alzheimer's disease (AD) is a complex neurodegenerative disorder, typified by the
pathological accumulation of ß-amyloid peptides (Aß) and neurofibrillary tangles within the …

Alzheimer's disease (AD) is an age-dependent neurodegenerative disease that causes
progressive cognitive impairment. The initiation and progression of AD has been linked to …