Recent studies have shown that on one hand, tumors need to obtain a sufficient energy
supply, and on the other hand they must evade the body's immune surveillance. Because of …

Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a
hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset …

Tumor mass and its microenvironment alter host immune system in various ways to promote
tumor growth. One of the modifications is evasion of immune surveillance by augmenting the …

Characterized by the expression of the critical transcription factor forkhead box protein P3,
regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the …

T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that
distinct metabolic changes impact the activation and differentiation of T cells. Tailoring …

Although targeting the tumor metabolism is performed in cooperation with immunotherapy in
the era of precision oncology, ignorance of immune cells' metabolism has resulted in …

Advances in immunotherapy have underscored the importance of antitumor immune
responses in controlling cancer. However, the tumor microenvironment (TME) imposes …

Tumor microenvironment is a special environment for tumor survival, which is characterized
by hypoxia, acidity, nutrient deficiency, and immunosuppression. The environment consists …

With the rapid rise of immunotherapy for cancer treatment, attention has focused on gaining
a better understanding of T-cell biology in the tumor microenvironment. Elucidating the …

Immunometabolism is an emerging discipline in cancer immunotherapy. Tumor tissues are
heterogeneous and influenced by metabolic reprogramming of the tumor immune …