Abstract P-glycoprotein (P-gp) antagonists inhibit ceramide metabolism at the juncture of
glycosylation. The purpose of this study was to test whether targeting P-gp would be a viable …

The role of glucosylceramide synthase (GCS) in regulating ceramide-induced apoptosis has
been widely studied. The purpose of this investigation was to evaluate the role of P …

The anticancer properties of ceramide, a sphingolipid with potent tumor-suppressor
properties, can be dampened via glycosylation, notably in multidrug resistance wherein …

Overexpression of glucosylceramide synthase (GCS), a pivotal enzyme in glycolipid
biosynthesis, contributes to cancer cell resistance to chemotherapy. We previously showed …

Ceramide glycosylation, through glucosylceramide synthase (GCS), allows cellular escape
from ceramide‐induced programmed cell death. This glycosylation event confers cancer cell …

The multidrug-resistant cancer cell lines NCI/AdR RES and MES-SA/DX-5 have higher
glycolipid levels and higher P-glycoprotein expression than the chemosensitive cell lines …

Background/Aim: P-glycoprotein (Pgp) expression in neoplastic cells is known to reduce cell
sensitivity to several cytotoxic Pgp substrates. A member of the ABC transporter family, Pgp …

Conversion of ceramide, a putative mediator of anticancer drug‐induced apoptosis, into
glucosylceramide, by the action of glucosylceramide synthase (GCS), has been implicated …

Resistance to natural product chemotherapy drugs is a major obstacle to successful cancer
treatment. This type of resistance is often acquired in response to drug exposure; however …

Alterations in metabolism of ceramide (Cer) to the noncytotoxic metabolite glucosylceramide
have been implicated in the multidrug resistance (MDR) phenomenon. This observation has …