First clinical‐grade porcine kidney xenotransplant using a human decedent model

PM Porrett, BJ Orandi, V Kumar, J Houp… - American Journal of …, 2022 - Wiley Online Library
A radical solution is needed for the organ supply crisis, and the domestic pig is a promising
organ source. In preparation for a clinical trial of xenotransplantation, we developed an in …

Results of two cases of pig-to-human kidney xenotransplantation

RA Montgomery, JM Stern, BE Lonze… - … England Journal of …, 2022 - Mass Medical Soc
Background Xenografts from genetically modified pigs have become one of the most
promising solutions to the dearth of human organs available for transplantation. The …

Pig kidney graft survival in a baboon for 136 days: longest life‐supporting organ graft survival to date

H Iwase, H Liu, M Wijkstrom, H Zhou… - …, 2015 - Wiley Online Library
The longest survival of a non‐human primate with a life‐supporting kidney graft to date has
been 90 days, although graft survival> 30 days has been unusual. A baboon received a …

Normal graft function after pig-to-human kidney xenotransplant

JE Locke, V Kumar, D Anderson, PM Porrett - JAMA surgery, 2023 - jamanetwork.com
Methods| In this case series, persons aged 18 years or older declared brain dead whose
families provided informed consent for study participation were eligible for study entry after …

Pig kidney xenotransplantation: progress toward clinical trials

DKC Cooper, H Hara, H Iwase… - Clinical …, 2021 - Wiley Online Library
Pig organ xenotransplantation offers a solution to the shortage of deceased human organs
for transplantation. The pathobiological response to a pig xenograft is complex, involving …

Xenotransplantation: past, present, and future

B Ekser, P Li, DKC Cooper - Current opinion in organ …, 2017 - journals.lww.com
Xenotransplantation: past, present, and future : Current Opinion in Organ Transplantation
Xenotransplantation: past, present, and future : Current Opinion in Organ Transplantation Log in …

Genetically engineered pig kidney transplantation in a brain‐dead human subject

DKC Cooper - Xenotransplantation, 2021 - Wiley Online Library
In September 2021, a kidney (with donor‐specific thymic tissue) from an α1, 3‐
galactosyltransferase gene‐knockout (GTKO) pig was transplanted into the groin (with …

[HTML][HTML] The resurgence of xenotransplantation

PJ Cowan, AJ Tector - American Journal of transplantation, 2017 - Elsevier
There has been an upsurge of interest in xenotransplantation in recent years. This
resurgence can attributed to a combination of factors. First, there has been a dramatic …

[HTML][HTML] Measuring success in pig to non-human-primate renal xenotransplantation: systematic review and comparative outcomes analysis of 1051 life-sustaining …

DJ Firl, JF Markmann - American Journal of Transplantation, 2022 - Elsevier
Facile gene editing has accelerated progress in pig to non-human-primate (NHP) renal
xenotransplantation, however, outcomes are considered inferior to NHP-allotransplantation …

Xenotransplantation of solid organs in the pig-to-primate model

B Ekser, P Rigotti, B Gridelli, DKC Cooper - Transplant immunology, 2009 - Elsevier
Xenotransplantation using pig organs could solve the significant increasing shortage of
donor organs for allotransplantation. In the last two decades, major progress has been made …