Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease
muscle mass and strength, and undermine postural stability, culminating in an elevated risk …

Abstract Purpose of Review Osteoporosis is an age-related disorder characterized by bone
loss and increased fracture susceptibility. Whether this is due to reduced loading in less …

Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Lack of physical activity causes bone loss and fractures not only in elderly people, but also
in bedridden patients or otherwise inactive youth. This is fast becoming one of the most …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Bone has a remarkable ability to adjust its mass and architecture in response to a wide
range of loads, from low-level gravitational forces to high-level impacts. A variety of types …

Abstract Purpose of Review The bone is able to adapt its structure to mechanical signals via
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …

Bones serve several mechanical functions, including acoustic amplification in the middle
ear, shielding vital organs from trauma, and serving as levers for muscles to contract against …

Deterioration of the immune and skeletal systems, each of which parallel obesity, reflects a
fragile interrelationship between adiposity and osteoimmunology. Using a murine model of …

Mechanotransduction is pivotal in the maintenance of homeostasis in different tissues and
involves multiple cell signaling pathways. In bone, mechanical stimuli regulate the balance …