Dendrimer-peptide conjugates for effective blockade of the interactions between SARS-CoV-2 spike protein and human ACE2 receptor

W Jeong, J Bu, P Mickel, Y Han, PA Rawding… - …, 2022 - ACS Publications
The coronavirus disease 2019 (COVID-19) pandemic has threatened the stability of global
healthcare, which is becoming an endemic issue. Despite the development of various …

SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection

C Zannella, A Chianese, A Monti, R Giugliano… - Pharmaceutics, 2023 - mdpi.com
Fusion is a key event for enveloped viruses, through which viral and cell membranes come
into close contact. This event is mediated by viral fusion proteins, which are divided into …

Rationally designed ACE2-derived peptides inhibit SARS-CoV-2

RC Larue, E Xing, AD Kenney, Y Zhang… - Bioconjugate …, 2020 - ACS Publications
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is a novel and highly
pathogenic coronavirus and is the causative agent of the coronavirus disease 2019 (COVID …

Effective ACE2 peptide–nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering

VSD Mesias, H Zhu, X Tang, X Dai, Y Guo… - Chemical …, 2021 - pubs.rsc.org
The infection of coronavirus initiates with the binding between its spike protein receptor
binding domain (RBD) and a human cellular receptor called angiotensin-converting enzyme …

Label-free analysis of binding and inhibition of SARS-Cov-19 spike proteins to ACE2 receptor with ACE2-derived peptides by surface plasmon resonance

F Abouhajar, R Chaudhuri, SN Valiulis… - ACS applied bio …, 2022 - ACS Publications
SARS-CoV-2 has been shown to enter and infect human cells via interactions between
spike protein (S glycoprotein) and angiotensin-converting enzyme 2 (ACE2). As such, it may …

Computational design and experimental validation of ACE2-derived peptides as SARS-CoV-2 receptor binding domain inhibitors

S Sarma, SM Herrera, X Xiao… - The Journal of …, 2022 - ACS Publications
The COVID-19 pandemic has caused significant social and economic disruption across the
globe. Cellular entry of SARS-CoV-2 into the human body is mediated via binding of the …

Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition

V Sanna, S Satta, T Hsiai, M Sechi - European Journal of Medicinal …, 2022 - Elsevier
Recently, a novel coronavirus, known as severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has raised global concerns, being the etiological agent of the current …

A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2

LM Behera, PK Gupta, M Ghosh… - The Journal of …, 2024 - ACS Publications
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus,
is the causative agent responsible for the spread of the COVID19 pandemic across the …

Targeting the receptor-binding motif of SARS-CoV-2 with D-peptides mimicking the ACE2 binding helix: lessons for inhibiting omicron and future variants of concern

PA Valiente, S Nim, JA Lee, S Kim… - Journal of Chemical …, 2022 - ACS Publications
The COVID-19 pandemic continues to spread around the world, with several new variants
emerging, particularly those of concern (VOCs). Omicron (B. 1.1. 529), a recent VOC with …

Synthetic peptides that antagonize the angiotensin-converting enzyme-2 (ACE-2) interaction with SARS-CoV-2 receptor binding spike protein

A Sadremomtaz, ZM Al-Dahmani… - Journal of medicinal …, 2021 - ACS Publications
The SARS-CoV-2 viral spike protein S receptor-binding domain (S-RBD) binds ACE2 on
host cells to initiate molecular events, resulting in intracellular release of the viral genome …