Deciphering breast cancer: from biology to the clinic

E Nolan, GJ Lindeman, JE Visvader - Cell, 2023 - cell.com
Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …

Molecular oncology of breast cancer

H Joshi, MF Press - The Breast, 2018 - Elsevier
Breast cancer, like other cancers, is a genetic disease. The disease is caused by acquired
molecular alterations during the lifetime of an individual and by inherited mutant genes. Risk …

[HTML][HTML] Breast cancer: origins and evolution

K Polyak - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
Breast cancer is not a single disease, but rather is composed of distinct subtypes associated
with different clinical outcomes. Understanding this heterogeneity is key for the development …

Molecular characterization and targeted therapeutic approaches in breast cancer

A Toss, M Cristofanilli - Breast cancer research, 2015 - Springer
Despite the wide improvements in breast cancer (BC) detection and adjuvant treatment, BC
is still responsible for approximately 40,000 deaths annually in the United States. Novel …

Extensive review on breast cancer its etiology, progression, prognostic markers, and treatment

H Swaminathan, K Saravanamurali, SA Yadav - Medical Oncology, 2023 - Springer
As the most frequent and vulnerable malignancy among women, breast cancer universally
manifests a formidable healthcare challenge. From a biological and molecular perspective, it …

Heterogeneity in breast cancer

K Polyak - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Breast cancer is a heterogeneous disease. There is a high degree of diversity between and
within tumors as well as among cancer-bearing individuals, and all of these factors together …

Molecular profiling: moving away from tumor philately

JS Reis-Filho, B Weigelt, D Fumagalli… - Science translational …, 2010 - science.org
Despite the remarkable enhancements in breast cancer classification and characterization,
an exhaustive comprehension of the underlying carcinogenic processes and an accurate …

Histological, molecular and functional subtypes of breast cancers

GK Malhotra, X Zhao, H Band, V Band - Cancer biology & therapy, 2010 - Taylor & Francis
Increased understanding of the molecular heterogeneity that is intrinsic to the various
subtypes of breast cancer will likely shape the future of breast cancer diagnosis, prognosis …

Breast cancer: multiple subtypes within a tumor?

SK Yeo, JL Guan - Trends in cancer, 2017 - cell.com
Breast cancer is a heterogeneous disease, and stratification of tumors is paramount to
achieve better clinical outcomes. While it is common to stratify and treat breast tumors as a …

[HTML][HTML] Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine

AG Rivenbark, SM O'Connor, WB Coleman - The American journal of …, 2013 - Elsevier
Breast cancer is noted for disparate clinical behaviors and patient outcomes, despite
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …