Introduction: Tear sampling is an attractive option for collecting biological samples in
ophthalmology clinics, as it offers a non-invasive alternative to other invasive techniques …

Introduction: Tear sampling is an attractive option for collecting biological samples in
ophthalmology clinics, as it offers a non-invasive alternative to other invasive techniques …

Human tears contain more than 1500 proteins that could be diagnostically relevant. To date,
numerous candidates on a biomarker of protein origin were identified for ocular and …

Tear fluid is emerging as a source of non-invasive biomarkers, both for ocular and systemic
conditions. Accurate quantification of tear proteins can be improved by standardizing …

Purpose: Extraction of tear protein from Schirmer's strip is a prerequisite for the proper
identification and screening of biomarkers in dry eye disease. The study compares different …

Purpose: We report the differences in protein identification using eight different extraction
techniques from tears collected by Schirmer Strips. The effect of separating the bulb from the …

Background Quantitative determination of tear proteins is critical to our understanding of
those ocular diseases with tear protein changes, but remains technically complex due to the …

Purpose Although various sampling methods of tears from conjunctival sac have been
reported, no previous study compared their effectiveness or efficiency based on protein …

Tears covering the ocular surface are important biofluids containing thousands of molecules,
including proteins, lipids, metabolites, nucleic acids, and electrolytes. Tears are valuable …

Background Human tear protein biomarkers are useful for detecting ocular and systemic
diseases. Unfortunately, existing tear film sampling methods (Schirmer strip; SS and …