When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification

KA Alexander, HW Tseng, M Salga, F Genêt… - Current osteoporosis …, 2020 - Springer
Abstract Purpose of Review Neurogenic heterotopic ossification (NHO) is the abnormal
formation of extra-skeletal bones in periarticular muscles after damage to the central …

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage‐mediated inflammation in muscle

F Genêt, I Kulina, C Vaquette, F Torossian… - The Journal of …, 2015 - Wiley Online Library
Neurological heterotopic ossification (NHO) is the abnormal formation of bone in soft tissues
as a consequence of spinal cord or traumatic brain injury. NHO causes pain, ankyloses …

Neurological heterotopic ossification: current understanding and future directions

RD Brady, SR Shultz, SJ McDonald, TJ O'Brien - Bone, 2018 - Elsevier
Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue
following a neurological condition, of which the most common are brain and spinal cord …

A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury

RD Brady, MZ Zhao, KR Wong, PM Casilla-Espinosa… - Bone, 2020 - Elsevier
Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in
soft tissue and joints in response to injury to the central nervous system. The ectopic bone …

Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injury

KA Alexander, HW Tseng, I Kulina, W Fleming… - Neurotrauma …, 2022 - liebertpub.com
Neurogenic heterotopic ossifications (NHOs) are incapacitating complications of traumatic
brain and spinal cord injuries (SCI) that manifest as abnormal bone formation in periarticular …

Neurological heterotopic ossification: novel mechanisms, prognostic biomarkers and prophylactic therapies

KR Wong, R Mychasiuk, TJ O'Brien, SR Shultz… - Bone Research, 2020 - nature.com
Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in
soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or …

Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification

HW Tseng, I Kulina, D Girard, J Gueguen… - Journal of Bone and …, 2020 - academic.oup.com
Neurogenic heterotopic ossifications (NHOs) form in periarticular muscles after severe
spinal cord (SCI) and traumatic brain injuries. The pathogenesis of NHO is poorly …

[PDF][PDF] The pathogenesis of heterotopic ossification after traumatic brain injury. A review of current literature

J Anthonissen, CT Steffen, A Hofmann… - Acta Orthop …, 2020 - actaorthopaedica.be
Neurogenic heterotopic ossification (NHO), mostly defined as a benign process of formation
of bone outside the skeletal system, after traumatic brain injury (TBI) is a musculoskeletal …

Peripheral denervation participates in heterotopic ossification in a spinal cord injury model

C Debaud, M Salga, L Begot, X Holy, M Chedik… - PloS one, 2017 - journals.plos.org
We previously reported the development of a new acquired neurogenic HO (NHO) mouse
model, combining spinal cord transection (SCI) and chemical muscle injury. Pathological …

Neurogenic heterotopic ossifications develop independently of granulocyte colony‐stimulating factor and neutrophils

HW Tseng, I Kulina, M Salga, W Fleming… - Journal of Bone and …, 2020 - academic.oup.com
Neurogenic heterotopic ossifications (NHOs) are incapacitating heterotopic bones in
periarticular muscles that frequently develop following traumatic brain or spinal cord injuries …