The functions and unique features of long intergenic non-coding RNA

JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

Long noncoding RNA (lincRNA), a new paradigm in gene expression control

E Deniz, B Erman - Functional & integrative genomics, 2017 - Springer
Long intergenic non-coding RNAs (lincRNAs) are defined as RNA transcripts that are longer
than 200 nucleotides. By definition, these RNAs must not have open reading frames that …

RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

S Geisler, J Coller - Nature reviews Molecular cell biology, 2013 - nature.com
The increased application of transcriptome-wide profiling approaches has led to an
explosion in the number of documented long non-coding RNAs (lncRNAs). While these new …

[HTML][HTML] lincRNAs: genomics, evolution, and mechanisms

I Ulitsky, DP Bartel - Cell, 2013 - cell.com
Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular …

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

MN Cabili, C Trapnell, L Goff, M Koziol… - Genes & …, 2011 - genesdev.cshlp.org
Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse
cellular processes. Determining the function of individual lincRNAs remains a challenge …

Long non-coding RNAs: definitions, functions, challenges and recommendations

JS Mattick, PP Amaral, P Carninci… - … reviews Molecular cell …, 2023 - nature.com
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

lncRNAs: linking RNA to chromatin

JL Rinn - Cold Spring Harbor perspectives in biology, 2014 - cshperspectives.cshlp.org
Numerous studies over the past decade have identified increasing numbers of long
noncoding RNAs (lncRNAs) across many organisms. Research since has shown that …

Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals

S Washietl, M Kellis, M Garber - Genome research, 2014 - genome.cshlp.org
Long intergenic noncoding RNAs (lincRNAs) play diverse regulatory roles in human
development and disease, but little is known about their evolutionary history and constraint …

Cellular functions of long noncoding RNAs

RW Yao, Y Wang, LL Chen - Nature cell biology, 2019 - nature.com
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs

TC Roberts, KV Morris, MS Weinberg - Epigenetics, 2014 - Taylor & Francis
Long non-coding RNAs (lncRNAs) are increasingly being recognized as epigenetic
regulators of gene transcription. The diversity and complexity of lncRNA genes means that …