Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Alzheimer's disease (AD) is a debilitating, chronic neurodegenerative disease. Genetic
studies involving genome-wide association studies (GWAS) and meta-analysis have …

Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Neuroinflammation is a pathological hallmark of Alzheimer's disease (AD), and microglia,
the brain's resident phagocyte, are pivotal for the immune response observed in AD …

Research into the function of microglia has dramatically accelerated during the last few
years, largely due to recent genetic findings implicating microglia in virtually every …

Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder
caused by fully penetrant single gene mutations in a minority of cases, while the majority of …

Alzheimer's disease (AD) is a highly heritable complex disease with no current effective
prevention or treatment. The majority of drugs developed for AD focus on the amyloid …

Polygenic risk scores have identified that genetic variants without genome‐wide significance
still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …

Recent human genetic studies have challenged long standing hypotheses about the chain
of events in Alzheimer's disease (AD), as the identification of genetic risk factors in microglial …