The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging
as an important target in the brain for the treatment or prevention of cognitive disorders. The …

Peroxisome proliferator–activated receptor-α (PPARα) regulates hepatic fatty acid
catabolism and mediates the metabolic response to starvation. Recently we found that …

The astrocyte marker, glial fibrillary acidic protein (GFAP), has essential functions in the
brain, but may trigger astroglial scarring when expressed in excess. Docosahexaenoic acid …

The harmony and function of the complex brain circuits and synapses are sustained mainly
by excitatory and inhibitory neurotransmission, neurotrophins, gene regulation, and factors …

n-3 PUFAs are essential for neuronal development and brain function. However, the
molecular mechanisms underlying their biological effects remain unclear. Here we …

DHA (docosahexaenoic acid, C22: 6, n− 3) has been shown to promote neurite growth and
synaptogenesis in embryonic hippocampal neurons, supporting the importance of DHA …

Docosahexaenoic acid (DHA, 22: 6n-3) is specifically enriched in the brain and mainly
anchored in the neuronal membrane, where it is involved in the maintenance of normal …

Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LC-PUFA),
highly enriched in the central nervous system, is critical for brain development and function …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act
as ligand-activated transcription factors. PPAR agonists have well-documented anti …

Abstract Docosahexaenoic acid (DHA, 22: 6n‐3), the major polyunsaturated fatty acid
accumulated in the brain during development, has been implicated in learning and memory …