The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif
ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus …

Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4
(CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis …

This review presents evidence that dual targeting of CCR2 and CCR5 has greater
therapeutic potential than targeting either receptor alone. A cardinal feature of inflammation …

Background/Aims: Hyperlipidemia induces dysfunction in the smooth muscle cells (SMCs) of
the blood vessels, and the vascular remodeling that ensues is a key proatherogenic factor …

Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …

To defense harmful stimuli or maintain the immune homeostasis, the body produces and
recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among …

The role of chemokines and their receptors in controlling several physiological and
pathological processes has only become evident in the last couple of years. From a sole …

Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can
be either detrimental or beneficial, depending on their phenotypes. In humans, classical …

The CXC chemokines, CXCL4,-9,-10,-11, CXCL4L1, and the CC chemokine CCL21,
activate CXC chemokine receptor 3 (CXCR3), a cell-surface G protein-coupled receptor …