[HTML][HTML] Immunogenicity of candidate MERS-CoV DNA vaccines based on the spike protein

SS Al-Amri, AT Abbas, LA Siddiq, A Alghamdi… - Scientific reports, 2017 - nature.com
MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to> 25 countries since
2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) …

Prospects for a MERS-CoV spike vaccine

Y Zhou, S Jiang, L Du - Expert review of vaccines, 2018 - Taylor & Francis
Introduction: Six years have passed since Middle East respiratory syndrome (MERS)
coronavirus (MERS-CoV), a newly emerging infectious virus, was first reported in 2012 …

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein

Y Chen, S Lu, H Jia, Y Deng, J Zhou… - Emerging microbes & …, 2017 - Taylor & Francis
Middle East respiratory syndrome coronavirus (MERS-CoV) has caused fatal infections,
some through hospital-acquired transmission, in affected regions since its emergence in …

A recombinant VSV-vectored MERS-CoV vaccine induces neutralizing antibody and T cell responses in rhesus monkeys after single dose immunization

R Liu, J Wang, Y Shao, X Wang, H Zhang, L Shuai… - Antiviral research, 2018 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV) has been a highly threatening
zoonotic pathogen since its outbreak in 2012. Similar to SARS-CoV, MERS-CoV belongs to …

Characterization of novel monoclonal antibodies against the MERS-coronavirus spike protein and their application in species-independent antibody detection by …

S Fukushi, A Fukuma, T Kurosu, S Watanabe… - Journal of virological …, 2018 - Elsevier
Abstract Since discovering the Middle East respiratory syndrome coronavirus (MERS-CoV)
as a causative agent of severe respiratory illness in the Middle East in 2012, serological …

Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice

C Wang, X Zheng, W Gai, G Wong, H Wang, H Jin… - Antiviral research, 2017 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV) has continued spreading since
its emergence in 2012 with a mortality rate of 35.6%, and is a potential pandemic threat …

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than …

C Ma, Y Li, L Wang, G Zhao, X Tao, CTK Tseng, Y Zhou… - Vaccine, 2014 - Elsevier
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) was originally identified
in Saudi Arabia in 2012. It has caused MERS outbreaks with high mortality in the Middle …

[HTML][HTML] A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses …

L Du, Z Kou, C Ma, X Tao, L Wang, G Zhao, Y Chen… - PloS one, 2013 - journals.plos.org
An emerging respiratory infectious disease with high mortality, Middle East respiratory
syndrome (MERS), is caused by a novel coronavirus (MERS-CoV). It was first reported in …

Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen

MP Nyon, L Du, CTK Tseng, CA Seid, J Pollet… - Vaccine, 2018 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 2040
patients and caused 712 deaths since its first appearance in 2012, yet neither pathogen …

[HTML][HTML] A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein

Y Li, Y Wan, P Liu, J Zhao, G Lu, J Qi, Q Wang, X Lu… - Cell research, 2015 - nature.com
Abstract The newly-emerging Middle East respiratory syndrome coronavirus (MERS-CoV)
can cause severe and fatal acute respiratory disease in humans. Despite global efforts, the …