Aim: To systematically investigate the genetic polymorphisms of the CYP3A4 gene in a Han
Chinese population. Materials & methods: The promoter and exons of CYP3A4 gene in …

Objectives: Cytochrome P450 3A4 (CYP3A4) is a major CYP enzyme in the liver and
intestine. It is involved in the metabolism of over 50% of all drugs currently in use. The …

Our study aimed to comprehensively investigate the genetic polymorphisms of CYP3A4 in
Han Chinese. We sequenced the gene regions of CYP3A4, including its promoter, exons …

Abstract Human cytochrome P450 2A6 (CYP2A6) has been shown to metabolically activate
carcinogens and mutagens. Genetic polymorphisms for CYP2A6 have been reported …

Objective To determine the frequencies of two functional single nucleotide polymorphisms,
CYP3A5* 3 and CYP3A5* 6, in the CYP3A5 gene in three distinct Asian ethnic groups …

BACKGROUND: Human cytochrome P450 3A evolved to catalyze the metabolism of
numerous common therapy drugs and endogenous molecules. Members of the CYP3A are …

Human cytochrome P450 3A4 is a major P450 enzyme in the liver and gastrointestinal tract.
It plays important roles in the metabolism of a wide variety of drugs, some endogenous …

Background: Human cytochrome P450 2A13 (CYP2A13) is involved in the activation of
numerous toxicants and carcinogens, especially in the metabolic activation of 4-(methyl …

Aim To observe the G-2964A and C734A genetic polymorphisms of human CYP1A2 in
Chinese population. Methods Polymerase chain reaction-restriction fragment length …

Heading Abstract Aims. To investigate the distribution characteristics of CYP2A6 activity in a
Chinese population and to examine the sex-related differences in CYP2A6 activities …