Simple Summary The tumor microenvironment of pancreatic cancer consists of dense
fibrotic stroma, which, to a certain extent, accounts for the relative drug resistance of this …

The gastrointestinal hormone cholecystokinin (CCK) can induce acute pancreatitis in
rodents through its action on acinar cells. Treatment with CCK, in combination with other …

Objectives Exogenous administration of cholecystokinin (CCK) induces hypertrophy and
hyperplasia of the pancreas with an increase in DNA content. We hypothesized that …

Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in
pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …

Simple Summary Our research team has identified the cholecystokinin-B receptor (or CCK-
BR) as a novel target for treatment of pancreatic cancer. CCK-BRs are over-expressed in …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction. It is now
known that pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma …

Pancreatic cancer is characterized by its late detection, aggressive growth, intense
infiltration into adjacent tissue, early metastasis, resistance to chemo-and radiotherapy and …

Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile
molecular behavior and complex tumor microenvironment. It has been recently postulated …

Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated
by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has …