Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …

Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is
critical in light of the increased incidence of dementia-related disorders forecasted in the …

Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with
klotho, a longevity factor, could enhance cognition in human-relevant models such as in …

Aging is the principal demographic risk factor for Alzheimer disease (AD), the most common
neurodegenerative disorder. Klotho is a key modulator of the aging process and, when …

Cognitive deficits are a major biomedical challenge—and engagement of the brain in
stimulating tasks improves cognition in aged individuals (;) and rodents, through unknown …

ABSTRACT A new gene, termed klotho, is associated with the suppression of several aging
phenotypes. Because high expression of klotho gene was detected in the brain, it would be …

Klotho is a putative age-suppressing gene whose overexpression in mice results in
extension of life span. The Klotho gene encodes a single-pass transmembrane protein …

A new gene, termed klotho, has been identified that is involved in the suppression of several
ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome …

Conventional studies of brain changes in normal aging have concentrated on gray matter as
the locus for cognitive dysfunction. However, there is accumulating evidence from studies of …

We have previously shown that myelin abnormalities characterize the normal aging process
of the brain and that an age-associated reduction in Klotho is conserved across species …