N6‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion

W Wang, Y He, L Wu, LL Zhai, LJ Chen… - Cancer …, 2023 - Wiley Online Library
Pancreatic cancer (PC) is a deadly disease, and its post‐transcriptional gene regulation
mechanism remains unclear. The abundant extracellular matrix (ECM) in PC plays an …

m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2

W Wang, Y He, LL Zhai, LJ Chen, LC Yao, L Wu… - Epigenetics, 2022 - Taylor & Francis
Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we
found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related …

[HTML][HTML] RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2 …

Z Tan, S Shi, J Xu, X Liu, Y Lei, B Zhang, J Hua… - Oncogene, 2022 - nature.com
Abstract RNA N6-methyladenosine (m6A) is an emerging regulator of mRNA modifications
and represents a novel player in tumorigenesis. Although it has functional significance in …

[HTML][HTML] Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

M Wang, J Liu, Y Zhao, R He, X Xu, X Guo, X Li, S Xu… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal human cancers. N 6-
methyladenosine (m 6 A), a common eukaryotic mRNA modification, plays critical roles in …

IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation

P Cao, Y Wu, D Sun, W Zhang, J Qiu, Z Tang… - Cancer …, 2023 - Wiley Online Library
Background Pancreatic carcinoma (PC) is a highly lethal cancer with an increasing mortality
rate, its five‐year survival rate is only approximately 4%. N6‐methyladenosine (m6A) …

[HTML][HTML] Suppression of Wnt/β-catenin Signaling in PDAC via METTL16-mediated N6-methyladenosine Modification of DVL2

L Yu, J Lu, N Xie, L Fang, S Chen, Y Wu… - Journal of …, 2023 - ncbi.nlm.nih.gov
Pancreatic cancer is a formidable cause of cancer-related deaths worldwide and has
witnessed a more than twofold increase in incidence over the last 25 years. The most …

[HTML][HTML] Gene Signature and Identification of Clinical Trait-Related m6 A Regulators in Pancreatic Cancer

J Hou, Z Wang, H Li, H Zhang, L Luo - Frontiers in genetics, 2020 - frontiersin.org
Pancreatic cancer (PC) has a very poor prognosis and is usually diagnosed only at an
advanced stage. The discovery of new biomarkers for PC will help in early diagnosis and a …

[HTML][HTML] N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2/MYC axis

WX Peng, F Liu, JH Jiang, H Yuan, Z Zhang, L Yang… - Genes & diseases, 2023 - Elsevier
Accumulating evidence indicates that RNA methylation at N 6-methyladenosine (m6A) plays
an important regulatory role in gene expression and aberrant mRNA m6A modification is …

[HTML][HTML] Genetic alterations and functional networks of m6A RNA methylation regulators in pancreatic cancer based on data mining

J Zeng, H Zhang, Y Tan, Z Wang, Y Li… - Journal of Translational …, 2021 - Springer
Background Pancreatic cancer is a fatal malignancy of the digestive system and the 5-year
survival rate remains low. Therefore, new molecular therapeutic targets are required to …

[HTML][HTML] RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3

Y Niu, Z Lin, A Wan, H Chen, H Liang, L Sun, Y Wang… - Molecular cancer, 2019 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most pervasive
modification in mRNA, and has been considered as a new layer of epigenetic regulation on …