Unveiling the potential of proteomic and genetic signatures for precision therapeutics in lung cancer management

S Srivastava, N Jayaswal, S Kumar, PK Sharma… - Cellular …, 2024 - Elsevier
Lung cancer's enduring global significance necessitates ongoing advancements in
diagnostics and therapeutics. Recent spotlight on proteomic and genetic biomarker research …

The role of genomics and proteomics in lung cancer early detection and treatment

MH Abbasian, AM Ardekani, N Sobhani, R Roudi - Cancers, 2022 - mdpi.com
Simple Summary Biomarkers for the prediction and efficacy of therapies are an urgent
necessity for lung cancer patients. In this article, we summarize genomic and proteomic …

[HTML][HTML] Lung cancer biomarkers, targeted therapies and clinical assays

JN Patel, JL Ersek, ES Kim - Translational lung cancer research, 2015 - ncbi.nlm.nih.gov
Until recently, the majority of genomic cancer research has been in discovery and validation;
however, as our knowledge of tumor molecular profiling improves, the idea of genomic …

An overview of lung cancer genomics and proteomics

CA Granville, PA Dennis - American journal of respiratory cell and …, 2005 - atsjournals.org
Lung cancer is the cause of nearly 170,000 cancer deaths in the United States each year,
accounting for nearly 25% of all deaths from cancer. The 5-yr survival rate for lung cancer …

[HTML][HTML] Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

A Zaman, TG Bivona - Annals of translational medicine, 2018 - ncbi.nlm.nih.gov
In lung cancer, genomics-driven comprehensive molecular profiling has identified novel
chemically and immunologically addressable vulnerabilities, resulting in an increasing …

High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications

S Ocak, ML Sos, RK Thomas… - European Respiratory …, 2009 - Eur Respiratory Soc
During the last decade, high-throughput technologies including genomic, epigenomic,
transcriptomic and proteomic have been applied to further our understanding of the …

Advances in genomic data and biomarkers: revolutionizing NSCLC diagnosis and treatment

JC Restrepo, D Dueñas, Z Corredor, Y Liscano - Cancers, 2023 - mdpi.com
Simple Summary In the field of non-small cell lung cancer (NSCLC), there have been
significant advancements in genomic data and bioinformatics tools, which have improved …

Molecular histology of lung cancer: from targets to treatments

SL Wood, M Pernemalm, PA Crosbie… - Cancer treatment …, 2015 - Elsevier
Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival
rate of less than 15%, despite significant advances in both diagnostic and therapeutic …

Individualized therapy in non-small-cell lung cancer: future versus current clinical practice

R Perez-Soler - Oncogene, 2009 - nature.com
Despite advances in the management of non-small-cell lung cancer (NSCLC), including the
introduction of targeted therapies such as epidermal growth factor receptor tyrosine kinase …

Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma

MA Gillette, S Satpathy, S Cao, SM Dhanasekaran… - Cell, 2020 - cell.com
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …