Morphine (MOR) is a strong analgesic that is often used in treatment of severe pains during
cancer treatment, and thus might be concomitantly used with anticancer drugs as cisplatin …

Morphine is an opioid analgesic drug often used for pain relief in cancer patients. However,
there is growing evidence that morphine may modulate tumor growth, progression and …

Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that
limits the clinical use of cisplatin as an anti-tumoral drug. Our study was conducted to …

Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant.
Pharmacological preconditioning mimicking ischemic preconditioning has been …

Background Cardiotoxicity is a major complication of anticancer drugs, including
anthracyclines and 5-fluorouracil (5-FU) and it can have detrimental effects both in patients …

Doxorubicin (DOX) is an anthracycline antibiotic that is widely used as a chemotherapeutic
agent. However, usefulness of this agent is limited due to its cardiotoxic effects. The aim of …

Doxorubicin (DOX) possesses a broad-spectrum antineoplastic activity; however, its clinical
application is impeded by cardiotoxicity. This study aimed to investigate the protective effect …

Morphine as an analgesic drug is used frequently in cancer patients. Contradictory results
have been achieved from previous studies related to morphine effects in different …

Methods: MDA. MB. 231 cells were treated with paclitaxel in the presence or absence of
morphine and examined for cell proliferation by the MTT assay. In addition, the effect of …

Background: The limiting factor in the use of cyclophosphamide (CYP) in cancer
chemotherapy is its induced oxidative cardiotoxicity. Objectives: This study aims to …