Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

The endothelial cells (ECs) that line the inner layer of blood vessels are responsible for
maintaining vascular homeostasis under physiological conditions. In the presence of …

Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions.
Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure …

Mechanical stress from blood flow has a significant effect on endothelial physiology, with a
key role in initiating vasoregulatory signals. Disturbances in blood flow, such as in regions of …

This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Significance: Forces are important in the cardiovascular system, acting as regulators of
vascular physiology and pathology. Residing at the blood vessel interface, cells (endothelial …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Endothelial cells live in a dynamic environment, where they are constantly exposed to
external hemodynamic forces and generate cytoskeletal-based endogenous forces. These …

Blood vessels are constantly exposed to mechanical stimuli such as shear stress due to flow
and pulsatile stretch. The extracellular matrix maintains the structural integrity of the vessel …