In multicellular organisms, oocytes and sperm undergo fusion during fertilization and the
resulting zygote gives rise to a new individual. The ability of zygotes to produce a fully …

Following fertilization in mammals, it is generally accepted that totipotent cells are exclusive
to the zygote and to each of the two blastomeres originating from the first mitotic division …

BACKGROUND Early mammalian blastomeres are thought to be flexible and totipotent
allowing the embryo to overcome perturbations in its organization during preimplantation …

The mammalian zygote is described as a totipotent cell in the literature, but this
characterization is elusive ignoring the molecular underpinnings. Totipotency can connote …

In mammals, the unicellular zygote starts the process of embryogenesis and differentiates
into all types of somatic cells, including both fetal and extraembryonic lineages—in a highly …

The mammalian zygote is a totipotent cell that generates all the cells of a new organism
through embryonic development. However, if one asks about the totipotency of blastomeres …

After a spermatozoon enters an oocyte, maternal factors accumulated in the oocyte
reprogram the genomes of the terminally differentiated oocyte and spermatozoon …

Cell and developmental studies have clarified how, by the time of implantation, the mouse
embryo forms three primary cell lineages: epiblast (EPI), primitive endoderm (PE), and …

Blastomeres of the early mouse embryo are thought to be equivalent in their developmental
properties at least until the eight-cell stage. However, the experiments that have led to this …

During preimplantation development, mammalian embryo cells (blastomeres) cleave,
gradually losing their potencies and differentiating into three primary cell lineages: epiblast …