Solid tumors consist of neoplastic cells, non-malignant stromal cells, and migratory
hematopoietic cells. Complex interactions between the cell types in this microenvironment …

Purpose Cancer cells, despite stemming from the own cells of their host, usually elicit an
immune response. This response usually enables elimination of cancer at its earliest stages …

Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that serves many
roles in inflammation and immunity; however, it is also involved in carcinogenesis. This is a …

Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that has been
reported to enhance the aggressiveness and metastatic potential of tumor cells. However …

Inflammatory cells and mediators are an essential component of the tumor
microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of …

Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

Interactions between tumor infiltrating leukocytes and tumor cells have been of great interest
because of the possibility that immune cells either interfere with tumor progression or …

The role of the immune system during cancer development is complex involving extensive
reciprocal interactions between genetically altered cells, adaptive and innate immune cells …

[Frontiers in Bioscience S2, 176-183, January 1, 2010] 176 Roles of inflammation in cancer
initiation, progression, and metastas Page 1 [Frontiers in Bioscience S2, 176-183, January 1 …

Macrophage migration inhibitory factor (MIF) emerged in recent years as an important
inflammation mediator, playing a prominent role in the pathogenesis of various types of …